Phenotype: | hypothalamus canonical Wnt signaling pathway process quality, ameliorated |
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Note: | This statement combines anatomy and/or ontology terms with phenotype quality terms to create a complete phenotype (EQ) statement. For detailed information on individual terms, click the hyperlinked term name. |
Name: | hypothalamus |
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Synonyms: | |
Definition: | Multi-tissue structure which is the largest portion of diencephalon and is ventrally located. The hypothalamus arises near the end of the segmentation period and the embryonic hypothalamic region gives rise to the neurohypophysis and other diencephalic nuclei. |
Ontology: | Anatomy Ontology [ZFA:0000032] |
Name: | canonical Wnt signaling pathway |
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Synonyms: | canonical Wnt receptor signaling pathway, canonical Wnt-activated signaling pathway, frizzled-1 receptor signaling pathway, Wnt receptor signaling pathway through beta-catenin, Wnt receptor signaling pathway via beta-catenin, Wnt receptor signalling pathway through beta-catenin |
Definition: | A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. |
Ontology: | GO: Biological Process [GO:0060070] QuickGO AmiGO |
Name: | process quality |
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Synonyms: | quality of a process, quality of occurrent, quality of process, relational quality of occurrent |
Definition: | A quality which inheres in an process. |
Ontology: | Phenotypic Quality Ontology [PATO:0001236] |
Tag: | ameliorated |
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Definition: | This annotation denotes a significantly rescued phenotype resulting from an additional reagent or mutation. |