tmRNA

Term ID

SO:0000584

Synonyms

• 10Sa RNA
• INSDC_feature:tmRNA
• ssrA

Definition

A tmRNA liberates a mRNA from a stalled ribosome. To accomplish this part of the tmRNA is used as a reading frame that ends in a translation stop signal. The broken mRNA is replaced in the ribosome by the tmRNA and translation of the tmRNA leads to addition of a proteolysis tag to the incomplete protein enabling recognition by a protease. Recently a number of permuted tmRNAs genes have been found encoded in two parts. TmRNAs have been identified in eubacteria and some chloroplasts but are absent from archeal and Eukaryote nuclear genomes. http://www.sanger.ac.uk/cgi-bin/Rfam/getacc?RF00023

References

• http://en.wikipedia.org/wiki/TmRNA

Ontology

Sequence Ontology