Search Ontology:
GO: Cellular Component

mitotic spindle assembly checkpoint MAD1-MAD2 complex

Term ID
GO:1990728
Synonyms
  • MAD1-MAD2 complex
Definition
A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex. (2)
References
Ontology
GO: Cellular Component    QuickGO    AmiGO
Relationships
is part of
is a type of
has_part
Phenotype
Phenotype caused by Genes
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