Search Ontology:
GO: Cellular Component

STING complex

Term ID
GO:1990231
Synonyms
  • stimulator of interferon genes complex
Definition
A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides. Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the innate immune response. (3)
References
Ontology
GO: Cellular Component    QuickGO    AmiGO
Relationships
is part of
is a type of
Phenotype
Phenotype caused by Genes
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