Search Ontology:
GO: Molecular Function

non-ribosomal peptide synthetase activity

Term ID
GO:1904091
Synonyms
  • peptidyl carrier protein
  • peptidyl carrier protein activity
  • peptidyl carrier protein activity involved in nonribosomal peptide biosynthesis
  • peptidyl carrier protein activity involved in nonribosomal peptide biosynthetic process
Definition
Catalysis of a multistep reaction that produce non-ribosomal peptides. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization. (2)
References
Ontology
GO: Molecular Function    QuickGO    AmiGO
Relationships
is part of
is a type of
has subtype
Phenotype
Phenotype caused by Genes