chromosomal 5-methylcytosine DNA demethylation, oxidation pathway

Term ID

GO:0141167

Synonyms

• epigenetic 5-methylcytosine DNA demethylation, oxidation pathway
• epigenetic DNA demethylation, oxidation pathway

Definition

An epigenetic cytosine DNA demethylation pathway that starts with the enzymatic oxidation of the 5-methylcytosine (5meC) to generate 5-hydroxymethylcytosine (5hmC), which successively converted to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). A DNA glycosylase (e. g. TDG) recognizes the intermediate bases 5fC and 5caC and excises the modified base to initiate its replacement with unmethylated cytosine through base excision repair. (3)

References

Ontology

GO: Biological Process    QuickGO    AmiGO