Search Ontology:
GO: Biological Process

integrated stress response signaling

Term ID
GO:0140467
Synonyms
  • ISR
Definition
The series of molecular signals generated in response to diverse stress stimuli required to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eIF2 alpha by one of four members of the eIF2a kinase family (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2), which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. 27629041
References
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
is a type of
has subtype
Phenotype
Phenotype caused by Genes
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