P-type transmembrane transporter activity

Term ID

GO:0140358

Synonyms

• E1-E2 ATPase
• P-type ATPase

Definition

Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. (2)

References

• TC:3.A.3
• Wikipedia:P-type_ATPase

Ontology

GO: Molecular Function    QuickGO    AmiGO