2-(3-amino-3-carboxypropyl)histidine synthase complex

Term ID

GO:0120513

Synonyms

• Dph1-Dph2 complex

Definition

A protein complex capable of catalysing the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the histidine residue of translation elongation factor 2 (EF2), which is the first step in the biosynthesis of diphthamide. The complex is a Dph2 homodimer in archaea and a Dph1-Dph2 heterodimer in eukaryotes. (2)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO