Search Ontology:
GO: Biological Process
calcineurin-mediated signaling
- Term ID
- GO:0097720
- Synonyms
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- calcineurin signaling
- calcineurin-mediated signalling
- Definition
- Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression. (3)
- References
- Ontology
- GO: Biological Process QuickGO AmiGO
- is a type of
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- has subtype
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- negatively regulated by
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- positively regulated by
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- regulated by
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Phenotype
Phenotype caused by Genes