Search Ontology:
GO: Molecular Function

14-3-3 protein binding

Term ID
GO:0071889
Synonyms
Definition
Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. (2)
References
Ontology
GO: Molecular Function    QuickGO    AmiGO
Relationships
is a type of
Phenotype
Phenotype caused by Genes