ERK5 cascade

Term ID

GO:0070375

Synonyms

• big MAP kinase signaling cascade
• BMK cascade
• BMK signaling pathway
• BMK signalling pathway
• BMK1 cascade
• ERK5 signaling pathway
• extracellular signal-regulated kinase 5 cascade
• MAPK7 cascade

Definition

A MAPK cascade containing at least the ERK5 MAP kinase (MAPK7; also called BMK1). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and of ERK5. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The ERK5 cascade is activated by stress, mitogens, and by G protein-coupled receptors, and results in cellular responses such as cell growth, cell differentiation and development. (5)

References

Ontology

GO: Biological Process    QuickGO    AmiGO