Search Ontology:
GO: Biological Process

necroptotic process

Term ID
GO:0070266
Synonyms
  • activation of necroptosis
  • activation of necroptosis by extracellular signals
  • activation of necroptosis in response to extracellular signals
  • activation of necroptosis of activated-T cells
  • establishment of necroptosis
  • establishment of necroptosis of activated-T cells
  • extracellular signal-induced necroptosis
  • induction of necroptosis
  • induction of necroptosis by extracellular signals
  • induction of necroptosis of activated-T cells
  • necroptosis
  • PARP-dependent cell death
  • parthanatos
  • programmed necrosis
  • programmed necrotic cell death
  • RIPK1-mediated regulated necrosis
  • TNF-induced necroptosis
Definition
A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. (5)
References
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
has parts
is a type of
negatively regulated by
positively regulated by
regulated by
Phenotype
Phenotype caused by Genes