intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Term ID

GO:0070059

Synonyms

• apoptosis in response to endoplasmic reticulum stress
• apoptosis in response to ER stress
• apoptosis triggered by ER stress
• endoplasmic reticulum stress-induced apoptosis
• ER stress-induced apoptosis
• intrinsic apoptotic signaling pathway induced by endoplasmic reticulum stress

Definition

The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen. 18701708

References

Ontology

GO: Biological Process    QuickGO    AmiGO