ubiquitin protein ligase activity

Term ID

GO:0061630

Synonyms

• ER-associated E3 ligase
• protein ubiquitination activity

Definition

Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S = X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. 22863777

References

• Reactome:R-HSA-1225956
• Reactome:R-HSA-1504190
• Reactome:R-HSA-183036
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• Reactome:R-HSA-4641159
• Reactome:R-HSA-4641246
• Reactome:R-HSA-4641253
• Reactome:R-HSA-5246693
• Reactome:R-HSA-5610737
• Reactome:R-HSA-5632648
• Reactome:R-HSA-5635856
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• Reactome:R-HSA-5654672
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• Reactome:R-HSA-5654684
• Reactome:R-HSA-5658424
• Reactome:R-HSA-5674022
• Reactome:R-HSA-5682858
• Reactome:R-HSA-5684071
• Reactome:R-HSA-5687081
• Reactome:R-HSA-5689111
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• Reactome:R-HSA-6781867
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• Reactome:R-HSA-6798373
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• Reactome:R-HSA-68946
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• Reactome:R-HSA-8848829
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• Reactome:R-HSA-8854041
• Reactome:R-HSA-8854051
• Reactome:R-HSA-8854628
• Reactome:R-HSA-8866546
• Reactome:R-HSA-8866856
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• Reactome:R-HSA-9706354
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• Reactome:R-HSA-9708517
• Reactome:R-HSA-9733316
• Reactome:R-HSA-9755304
• Reactome:R-HSA-9755505
• Reactome:R-HSA-9759154
• Reactome:R-HSA-9759172
• Reactome:R-HSA-9762091
• Reactome:R-HSA-9766645
• Reactome:R-HSA-990526

Ontology

GO: Molecular Function    QuickGO    AmiGO