coenzyme F420-dependent bicyclic nitroimidazole catabolic process

Term ID

GO:0052799

Synonyms

• coenzyme F420-dependent nitroimidazole breakdown
• coenzyme F420-dependent nitroimidazole catabolism
• coenzyme F420-dependent nitroimidazole reduction
• coenzyme F420-dependent nitroreductase activity

Definition

The breakdown of a bicyclic nitroimidazole into simpler components in a process that requires coenzyme F420 and produces reactive nitrogen species. Hydride, from reduced coenzyme F420, is added to the bicyclic nitroimidazole, resulting in unstable substances that break down to form three stable products. The elimination of nitrous acid produces the corresponding des-nitroimidazole; hydrolysis produces a related compound; and further reduction creates an aromatic hydroxylamine metabolite that degrades further. These reactions release hyponitrous acid and nitrous acid, which is unstable and disproportionates into nitric oxide (NO) and other reactive nitrogen intermediates. (2)

References

Ontology

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