Search Ontology:
GO: Biological Process
lysine biosynthetic process via alpha-aminoadipate and saccharopine
- Term ID
- GO:0051975
- Synonyms
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- lysine biosynthesis via aminoadipic acid and saccharopine
- lysine biosynthetic process via aminoadipic acid and saccharopine
- Definition
- The chemical reactions and pathways resulting in the formation of lysine via the intermediates alpha-aminoadipic acid and saccharopine. This pathway is used by yeast and fungi to synthesize the essential amino acid L-lysine, and pathway intermediates are often incorporated into secondary metabolic processes. The pathway proceeds as follows: alpha-ketoglutarate is converted to homocitrate, which is metabolized to 3-carboxyhex-2-enedioate and then homoisocitrate. This is then decarboxylated to form alpha-ketoadipate, which is then converted to alpha-aminoadipate. This is then reduced to form alpha-aminoadipate 6-semialdehyde, which is metabolized to saccharopine and finally L-lysine.
- References
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- MetaCyc:LYSINE-AMINOAD-PWY
- Ontology
- GO: Biological Process QuickGO AmiGO
- is a type of
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- negatively regulated by
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- positively regulated by
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- regulated by
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Phenotype
Phenotype caused by Genes