N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity

Term ID

GO:0050509

Synonyms

• heparan glucuronyltransferase II activity
• N-acetylglucosaminyl-proteoglycan 4-b-glucuronosyltransferase activity
• N-acetylglucosaminylproteoglycan beta-1,4-glucuronyltransferase activity
• UDP-alpha-D-glucuronate:N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan 4-beta-glucuronosyltransferase activity

Definition

Catalysis of the reaction: 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-alpha-D-glucuronate = 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n+1)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H+ + UDP. 2.4.1.225

References

• EC:2.4.1.225
• MetaCyc:2.4.1.225-RXN
• RHEA:20908
• Reactome:R-HSA-2022856
• Reactome:R-HSA-2076392
• Reactome:R-HSA-3656257
• Reactome:R-HSA-3656267
• Reactome:R-HSA-9036285
• Reactome:R-HSA-9036289

Ontology

GO: Molecular Function    QuickGO    AmiGO