glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

Term ID

GO:0050508

Synonyms

• alpha-N-acetylglucosaminyltransferase II activity
• glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-a-N-acetylglucosaminyltransferase activity
• glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N-acetylglucosaminyltransferase activity
• UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity

Definition

Catalysis of the reaction: 3-O-{[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-{alpha-D-GlcNAc-[(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc](n)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl}-L-seryl-[protein] + H+ + UDP. 2.4.1.224

References

• EC:2.4.1.224
• MetaCyc:2.4.1.224-RXN
• RHEA:16213
• Reactome:R-HSA-2022851
• Reactome:R-HSA-2022919
• Reactome:R-HSA-3656254
• Reactome:R-HSA-3656261
• Reactome:R-HSA-9036283
• Reactome:R-HSA-9036290

Ontology

GO: Molecular Function    QuickGO    AmiGO