Search Ontology:
GO: Molecular Function
cholate-CoA ligase activity
- Term ID
- GO:0047747
- Synonyms
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- 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate--CoA ligase activity
- 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate-CoA ligase activity
- 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate:CoA ligase (AMP-forming) activity
- 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA ligase activity
- 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoate-CoA synthetase activity
- 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl coenzyme A synthetase activity
- 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate-CoA ligase activity
- 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanate:CoA ligase (AMP-forming)
- 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA ligase activity
- 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate-CoA synthetase activity
- 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl coenzyme A synthetase activity
- BAL activity
- bile acid CoA ligase activity
- bile acid coenzyme A ligase activity
- cholate thiokinase activity
- cholate:CoA ligase (AMP-forming)
- cholic acid:CoA ligase activity
- cholic thiokinase activity
- choloyl coenzyme A synthetase activity
- choloyl-CoA synthetase activity
- cholyl-CoA synthetase activity
- THCA-CoA ligase activity
- trihydroxycoprostanoyl-CoA synthetase activity
- Definition
- Catalysis of the reactions: (1) ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA and (2) ATP + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA. This reaction is the first step in the conjugation of bile acids with amino acids, converting bile acids into their acyl-CoA thioesters. Chenodeoxycholate, deoxycholate, lithocholate and trihydroxycoprostanoate can also act as substrates. 6.2.1.7
- References
-
- EC:6.2.1.7
- MetaCyc:CHOLATE--COA-LIGASE-RXN
- Ontology
- GO: Molecular Function QuickGO AmiGO
- is a type of
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Phenotype
Phenotype caused by Genes