pyruvate dehydrogenase complex

Term ID

GO:0045254

Synonyms

• dihydrolipoyl dehydrogenase complex
• pyruvate dehydrogenase complex (lipoamide)

Definition

A multi-enzyme complex that catalyzes the oxidative decarboxylation of pyruvate to form acetyl-CoA. The complex comprises multiple copies of three enzymes referred to as E1, E2 and E3: pyruvate dehydrogenase (E1, which may be a homodimer or a heterotetramer of two alpha and two beta subunits, depending on species), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Additional proteins may also be present. 36863425

References

• Wikipedia:Pyruvate_dehydrogenase_complex

Ontology

GO: Cellular Component    QuickGO    AmiGO