nuclear SCF ubiquitin ligase complex

Term ID

GO:0043224

Synonyms

• nuclear cullin complex
• nuclear SCF complex
• nuclear Skp1/Cul1/F-box protein complex

Definition

A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). (2)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO