Search Ontology:
GO: Biological Process

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Term ID
GO:0042771
Synonyms
  • DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
Definition
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
References
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
is a type of
negatively regulated by
positively regulated by
regulated by
Phenotype
Phenotype caused by Genes