Search Ontology:
GO: Biological Process

error-prone translesion synthesis

Term ID
GO:0042276
Synonyms
  • error-prone postreplication DNA repair
  • mutagenic postreplication DNA repair
  • mutagenic PRR
Definition
The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites. 11485998
References
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
is a type of
negatively regulated by
positively regulated by
regulated by
Phenotype
Phenotype caused by Genes