Search Ontology:
GO: Biological Process

symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity

Term ID
GO:0039562
Synonyms
  • disruption by virus of host JAK-STAT cascade via inhibition of STAT activity
  • inhibition by virus of host STAT activity
  • suppression by virus of host JAK-STAT cascade via inhibition of STAT activity
  • suppression by virus of host signal transducer and activator of transcription activity
  • suppression by virus of host STAT activity
Definition
A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.
References
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
is a type of
has subtype
Phenotype
Phenotype caused by Genes