Search Ontology:
GO: Biological Process
symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity
- Term ID
- GO:0039562
- Synonyms
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- disruption by virus of host JAK-STAT cascade via inhibition of STAT activity
- inhibition by virus of host STAT activity
- suppression by virus of host JAK-STAT cascade via inhibition of STAT activity
- suppression by virus of host signal transducer and activator of transcription activity
- suppression by virus of host STAT activity
- Definition
- A process in which a symbiont interferes with, inhibits or disrupt a JAK-STAT signal cascade in the host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.
- References
- Ontology
- GO: Biological Process QuickGO AmiGO
- is a type of
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- has subtype
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Phenotype
Phenotype caused by Genes