Search Ontology:
GO: Biological Process

symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity

Term ID
GO:0039554
Synonyms
  • inhibition by virus of host MDA-5 signaling
  • inhibition of host IFIH1/MDA5 by virus
  • Inhibition of host MDA5 by virus
  • suppression by virus of host IFIH1 signaling pathway
  • suppression by virus of host MDA-5 activity
  • suppression by virus of host MDA-5 signaling pathway
  • suppression by virus of host MDA-5 signalling pathway
  • suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity
Definition
A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. (2)
References
  • VZ:603
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
is a type of
Phenotype
Phenotype caused by Genes