symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity

Term ID

GO:0039554

Synonyms

• inhibition by virus of host MDA-5 signaling
• inhibition of host IFIH1/MDA5 by virus
• Inhibition of host MDA5 by virus
• suppression by virus of host IFIH1 signaling pathway
• suppression by virus of host MDA-5 activity
• suppression by virus of host MDA-5 signaling pathway
• suppression by virus of host MDA-5 signalling pathway
• suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity

Definition

A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. (2)

References

• VZ:603

Ontology

GO: Biological Process    QuickGO    AmiGO