Search Ontology:
GO: Biological Process
symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MDA-5 activity
- Term ID
- GO:0039554
- Synonyms
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- inhibition by virus of host MDA-5 signaling
- inhibition of host IFIH1/MDA5 by virus
- Inhibition of host MDA5 by virus
- suppression by virus of host IFIH1 signaling pathway
- suppression by virus of host MDA-5 activity
- suppression by virus of host MDA-5 signaling pathway
- suppression by virus of host MDA-5 signalling pathway
- suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity
- Definition
- A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines. (2)
- References
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- VZ:603
- Ontology
- GO: Biological Process QuickGO AmiGO
- is a type of
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Phenotype
Phenotype caused by Genes