symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity

Term ID

GO:0039548

Synonyms

• inhibition of host IRF3 by virus
• inhibition of IRF3-dependent antiviral response
• suppression by virus of host interferon regulatory factor 3
• suppression by virus of host IRF3 activity
• suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity

Definition

A process in which a symbiont interferes with, inhibits or disrupts a cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes. 21632562

References

• VZ:757

Ontology

GO: Biological Process    QuickGO    AmiGO