Search Ontology:
GO: Biological Process

non-canonical NF-kappaB signal transduction

Term ID
GO:0038061
Synonyms
  • NIK-IKK kinase cascade
  • NIK-IKK signaling pathway
  • NIK-IKK-alpha cascade
  • NIK/NF-kappaB cascade
  • NIK/NF-kappaB signal transduction
  • NIK/NF-kappaB signaling
  • non-canonical NF-KB signaling
  • noncanonical NF-kappaB signaling
  • noncanonical nuclear factor kappaB (NF-kappaB) pathway
  • p52-dependent NF-kappaB signaling
Definition
An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF). (3)
References
Ontology
GO: Biological Process    QuickGO    AmiGO
Relationships
has parts
is a type of
negatively regulated by
positively regulated by
regulated by
Phenotype
Phenotype caused by Genes