Search Ontology:
GO: Biological Process
non-canonical NF-kappaB signal transduction
- Term ID
- GO:0038061
- Synonyms
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- NIK-IKK kinase cascade
- NIK-IKK signaling pathway
- NIK-IKK-alpha cascade
- NIK/NF-kappaB cascade
- NIK/NF-kappaB signal transduction
- NIK/NF-kappaB signaling
- non-canonical NF-KB signaling
- noncanonical NF-kappaB signaling
- noncanonical nuclear factor kappaB (NF-kappaB) pathway
- p52-dependent NF-kappaB signaling
- Definition
- An intracellular signaling cassette characterized by the NIK-dependent processing and activation of NF-kappaB. Begins with activation of the NF-kappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-kappa B2 protein (p100) leading to p100 processing and release of an active NF-kappaB (p52). The non-canonical NF-kappaB signaling pathway is generally activated by ligands of the TNF receptor superfamily, including lymphotoxin beta (LTB), CD40, OX40, RANK, TWEAK and B cell-activating factor (BAFF). (3)
- References
- Ontology
- GO: Biological Process QuickGO AmiGO
- has parts
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- is a type of
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- negatively regulated by
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- positively regulated by
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- regulated by
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Phenotype
Phenotype caused by Genes