RNA N6-methyladenosine methyltransferase complex

Term ID

GO:0036396

Synonyms

• m(6)A writer complex
• m6A methyltransferase complex
• METTL3-METTL14-WTAP methyltransferase complex
• MIS complex
• Mum2, Ime4, and Slz1 complex
• WMM complex

Definition

A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B). (6)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO