transcription factor AP-1 complex

Term ID

GO:0035976

Synonyms

• Activating protein 1 complex
• AP-1 complex
• AP1 complex
• transcription factor AP1 complex

Definition

A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes. (3)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO