NAD-dependent protein lysine deacetylase activity

Term ID

GO:0034979

Synonyms

• NAD(+)-dependent protein deacetylase
• NAD(+)-dependent protein deacylase
• NAD-dependent protein deacetylase activity
• protein acetyllysine N-acetyltransferase
• protein lysine deacetylase
• protein lysine deacylase

Definition

Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. This reaction transfers an acetyl group from a protein to NAD, producing nicotinamide.

References

• EC:2.3.1.286
• RHEA:43636
• Reactome:R-HSA-3371467
• Reactome:R-HSA-5211239
• Reactome:R-HSA-5685953
• Reactome:R-HSA-5688289
• Reactome:R-HSA-5688294
• Reactome:R-HSA-9620532
• Reactome:R-HSA-9667952
• Reactome:R-HSA-9854463

Ontology

GO: Molecular Function    QuickGO    AmiGO