deoxyhypusine synthase activity

Term ID

GO:0034038

Synonyms

• (4-aminobutyl)lysine synthase
• eIF-5A-deoxyhypusine synthase activity
• spermidine dehydrogenase

Definition

Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine. Four sub-reactions have been identified,in which the intermediates remain tightly associated with the enzyme: spermidine + NAD+ = dehydrospermidine + NADH; dehydrospermidine + [enzyme]-lysine = N-(4-aminobutylidene)-[enzyme]-lysine + propane-1,3-diamine; N-(4-aminobutylidene)-[enzyme]-lysine + [eIF5A-precursor]-lysine = N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + [enzyme]-lysine; N-(4-aminobutylidene)-[eIF5A-precursor]-lysine + NADH + H+ = [eIF5A-precursor]-deoxyhypusine + NAD+.

References

• EC:2.5.1.46
• MetaCyc:2.5.1.46-RXN
• RHEA:33299
• Reactome:R-HSA-204617
• Reactome:R-HSA-204647

Ontology

GO: Molecular Function    QuickGO    AmiGO