Search Ontology:
GO: Cellular Component

death-inducing signaling complex

Term ID
GO:0031264
Synonyms
  • death receptor-induced signaling complex
  • death receptor-induced signalling complex
  • death-inducing signalling complex
  • DISC
  • DISC protein complex
Definition
A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. (3)
References
Ontology
GO: Cellular Component    QuickGO    AmiGO
Relationships
is a type of
has subtype
Phenotype
Phenotype caused by Genes
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