Search Ontology:
GO: Molecular Function
nuclear receptor coactivator activity
- Term ID
- GO:0030374
- Synonyms
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- ligand-activated RNA polymerase II transcription factor binding transcription factor activity
- ligand-dependent nuclear receptor transcription co-activator activity
- ligand-dependent nuclear receptor transcription coactivator activity
- nuclear receptor transcription coactivator activity
- transcription factor activity, ligand-activated RNA polymerase II transcription factor binding
- Definition
- A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.
- References
- Ontology
- GO: Molecular Function QuickGO AmiGO
- is a type of
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Phenotype
Phenotype caused by Genes