Search Ontology:
GO: Cellular Component

AP-2 adaptor complex

Term ID
GO:0030122
Synonyms
  • HA2
  • HA2 clathrin adaptor
Definition
A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). (4)
References
Ontology
GO: Cellular Component    QuickGO    AmiGO
Relationships
is part of
is a type of
Phenotype
Phenotype caused by Genes