Search Ontology:
GO: Cellular Component

serine palmitoyltransferase complex

Term ID
GO:0017059
Synonyms
  • serine C-palmitoyltransferase complex
  • SPOTS complex
Definition
A protein complex that catalyses the condensation of L-serine with palmitoyl-CoA to form 3-ketosphinganine, the sphingoid base which is the starting point for all sphingolipids. In bacteria the enzyme is a cytoplasmic homodimer, whereas in eukaryotes the enzyme is a multiprotein complex localised to the endoplasmic reticulum. The eukaryotic complex consists of catalytic components (SPTLC1, SPTLC2 and SPTLC3 in humans; LCB1 and LCB2 in S. cerevisiae) and regulatory components, which include activators (SPTSSA/SPTSSB in humans, TSC3 in S. cerevisiae) and negative regulators (ORMDL1/ORMDL2/ORMDL3 in humans, ORM1/2 in S. cerevisiae ). (2)
References
Ontology
GO: Cellular Component    QuickGO    AmiGO
Relationships
is a type of
Phenotype
Phenotype caused by Genes
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