core-binding factor complex

Term ID

GO:0016513

Synonyms

• AML1 complex
• CBF complex
• PEPB2 complex

Definition

A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit. (2)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO