catechol O-methyltransferase activity

Term ID

GO:0016206

Synonyms

• catechol methyltransferase activity
• catecholamine O-methyltransferase activity
• COMT I
• COMT II
• MB-COMT (membrane-bound form of catechol-O-methyltransferase)
• S-adenosyl-L-methionine:catechol O-methyltransferase activity
• S-COMT (soluble form of catechol-O-methyltransferase)

Definition

Catalysis of the reaction: a catechol + S-adenosyl-L-methionine = a guaiacol + H+ + S-adenosyl-L-homocysteine. Acts on catechols and on catecholamines such as adrenaline or noradrenaline. 2.1.1.6

References

• EC:2.1.1.6
• MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN
• RHEA:17877
• Reactome:R-HSA-175983
• Reactome:R-HSA-8955010

Ontology

GO: Molecular Function    QuickGO    AmiGO