Search Ontology:
GO: Molecular Function

fatty acid elongase activity

Term ID
GO:0009922
Synonyms
  • condensing enzyme
  • elongation of very long chain fatty acids activity
  • ELOVL
  • very-long-chain 3-ketoacyl-CoA synthase
  • very-long-chain 3-oxoacyl-CoA synthase
  • very-long-chain beta-ketoacyl-CoA synthase
Definition
Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit. (2)
References
  • EC:2.3.1.199
  • MetaCyc:RXN-7697
  • RHEA:32727
  • Reactome:R-HSA-2046083
  • Reactome:R-HSA-2046088
  • Reactome:R-HSA-2046090
  • Reactome:R-HSA-2046094
  • Reactome:R-HSA-2046095
  • Reactome:R-HSA-2046100
  • Reactome:R-HSA-548800
  • Reactome:R-HSA-548814
  • Reactome:R-HSA-548815
  • Reactome:R-HSA-548830
Ontology
GO: Molecular Function    QuickGO    AmiGO
Relationships
is a type of
Phenotype
Phenotype caused by Genes