DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity

Term ID

GO:0008657

Synonyms

DNA gyrase inhibitor activity

Definition

Binds to and stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2.

References

Ontology

GO: Molecular Function QuickGO AmiGO

Relationships

is a type of: ATPase inhibitor activity DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity enzyme inhibitor activity

ATPase inhibitor activity DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity enzyme inhibitor activity Show first 5 Terms
negatively regulates: DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity

DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity Show first 5 Terms

Phenotype

Phenotype caused by Genes