[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity

Term ID

GO:0008467

Synonyms

• 3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase
• 3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity
• 3-OST-1 activity
• glucosaminyl 3-O-sulfotransferase activity
• heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity
• heparin-glucosamine 3-O-sulfotransferase activity
• heparin-glucosamine 3-O-sulphotransferase activity
• isoform/isozyme 1 (3-OST-1, HS3ST1)

Definition

Catalysis of the reaction: 3'-phosphoadenylyl sulfate + alpha-D-glucosaminyl-(heparan sulfate)(n) = 3-sulfo-alpha-D-glucosaminyl-(heparan sulfate)(n) + adenosine 3',5'-bisphosphate + H+. The (heparan sulfate)-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S. 2.8.2.23

References

• EC:2.8.2.23
• MetaCyc:2.8.2.23-RXN
• RHEA:15461
• Reactome:R-HSA-2076383
• Reactome:R-HSA-2076611

Ontology

GO: Molecular Function    QuickGO    AmiGO