cholesterol monooxygenase (side-chain-cleaving) activity

Term ID

GO:0008386

Synonyms

• C27-side chain cleavage enzyme
• cholesterol 20-22-desmolase activity
• cholesterol C(20-22) desmolase activity
• cholesterol C20-22 desmolase activity
• cholesterol desmolase activity
• cholesterol side-chain cleavage enzyme activity
• cholesterol side-chain-cleaving enzyme activity
• cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)
• Cyp11a1
• cytochrome P-450(scc) activity
• cytochrome P-450scc
• cytochrome p450(scc) activity
• cytochrome p450scc
• desmolase, steroid 20-22
• enzymes, cholesterol side-chain-cleaving
• steroid 20-22 desmolase activity
• steroid 20-22-lyase activity

Definition

Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O. 1.14.15.6

References

• EC:1.14.15.6
• MetaCyc:1.14.15.6-RXN
• RHEA:35739
• Reactome:R-HSA-193054
• Reactome:R-HSA-193065
• Reactome:R-HSA-193101

Ontology

GO: Molecular Function    QuickGO    AmiGO