Search Ontology:

GO: Molecular Function

cholesterol 7-alpha-monooxygenase activity

Term ID

GO:0008123

Synonyms

cholesterol 7-alpha-hydroxylase activity
cholesterol 7alpha-hydroxylase activity
cholesterol 7alpha-monooxygenase activity
cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
cytochrome P450 CYP7A1

Definition

Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O. 1.14.14.23

References

EC:1.14.14.23
MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN
RHEA:21812
Reactome:R-HSA-192051

Ontology

GO: Molecular Function QuickGO AmiGO

Relationships

is a type of: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen steroid 7-alpha-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen steroid 7-alpha-hydroxylase activity Show first 5 Terms

Phenotype

Phenotype caused by Genes