cholesterol 7-alpha-monooxygenase activity

Term ID

GO:0008123

Synonyms

cholesterol 7-alpha-hydroxylase activity
cholesterol 7alpha-hydroxylase activity
cholesterol 7alpha-monooxygenase activity
cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)
cytochrome P450 CYP7A1

Definition

Catalysis of the reaction: cholesterol + O2 + reduced [NADPH--hemoprotein reductase] = 7alpha-hydroxycholesterol + H+ + H2O + oxidized [NADPH--hemoprotein reductase].

References

EC:1.14.14.23
MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN
RHEA:21812
Reactome:R-HSA-192051

Ontology

GO: Molecular Function QuickGO AmiGO

Relationships

is a type of: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen steroid 7-alpha-hydroxylase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen steroid 7-alpha-hydroxylase activity Show first 5 Terms

Phenotype

Phenotype caused by Genes