peptide-methionine (S)-S-oxide reductase activity

Term ID

GO:0008113

Synonyms

• methionine S-oxide reductase (S-form oxidizing) activity
• methionine S-oxide reductase activity
• methionine sulfoxide (protein) reductase activity
• methionine sulfoxide reductase A activity
• methionine sulfoxide reductase activity
• methionine sulphoxide reductase A activity
• MsrA
• peptide Met(O) reductase activity
• peptide methionine sulfoxide reductase activity
• peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity
• peptide-methionine-(S)-S-oxide reductase activity
• protein-methionine-S-oxide reductase activity

Definition

Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. (2)

References

• EC:1.8.4.11
• MetaCyc:RXN-8668
• RHEA:14217
• Reactome:R-HSA-1222363
• Reactome:R-HSA-5676940

Ontology

GO: Molecular Function    QuickGO    AmiGO