I-kappaB phosphorylation

Term ID

GO:0007252

Synonyms

IkappaB phosphorylation
IKB phosphorylation
inhibitor of kappaB phosphorylation
inhibitor of NF-kappaB phosphorylation

Definition

The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. (2)

References

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

is part of: canonical NF-kappaB signal transduction

canonical NF-kappaB signal transduction Show first 5 Terms
has parts: IkappaB kinase activity

IkappaB kinase activity Show first 5 Terms
is a type of: protein phosphorylation

protein phosphorylation Show first 5 Terms
negatively regulated by: negative regulation of I-kappaB phosphorylation

negative regulation of I-kappaB phosphorylation Show first 5 Terms
positively regulated by: positive regulation of I-kappaB phosphorylation

positive regulation of I-kappaB phosphorylation Show first 5 Terms
regulated by: regulation of I-kappaB phosphorylation

regulation of I-kappaB phosphorylation Show first 5 Terms

Phenotype

Phenotype caused by Genes