Search Ontology:
GO: Biological Process
G protein-coupled receptor signaling pathway
- Term ID
- GO:0007186
- Synonyms
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- dimeric G-protein coupled receptor signaling pathway
- dimeric G-protein coupled receptor signalling pathway
- G protein coupled receptor protein signaling pathway
- G protein coupled receptor protein signalling pathway
- G-protein coupled receptor protein signal transduction
- G-protein coupled receptor protein signaling pathway
- G-protein coupled receptor signaling pathway via GPCR dimer
- G-protein coupled receptor signalling pathway
- G-protein-coupled receptor protein signalling pathway
- GPCR signaling pathway
- GPCR signalling pathway
- Definition
- The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. (3)
- References
- Ontology
- GO: Biological Process QuickGO AmiGO
- has parts
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- is a type of
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- has subtype
- has_part
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- negatively regulated by
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- positively regulated by
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- regulated by
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Phenotype
Phenotype caused by Genes