G protein-coupled receptor signaling pathway

Term ID

GO:0007186

Synonyms

dimeric G-protein coupled receptor signaling pathway
dimeric G-protein coupled receptor signalling pathway
G protein coupled receptor protein signaling pathway
G protein coupled receptor protein signalling pathway
G-protein coupled receptor protein signal transduction
G-protein coupled receptor protein signaling pathway
G-protein coupled receptor signaling pathway via GPCR dimer
G-protein coupled receptor signalling pathway
G-protein-coupled receptor protein signalling pathway
GPCR signaling pathway
GPCR signalling pathway

Definition

The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. (3)

References

Reactome:R-HSA-373076
Reactome:R-HSA-388396

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

has parts: G protein-coupled receptor activity ion channel regulator activity involved in G protein-coupled receptor signaling pathway potassium channel activator activity involved in G protein-coupled receptor signaling pathway

G protein-coupled receptor activity ion channel regulator activity involved in G protein-coupled receptor signaling pathway potassium channel activator activity involved in G protein-coupled receptor signaling pathway Show first 5 Terms
is a type of: signal transduction

signal transduction Show first 5 Terms
has subtype: adenylate cyclase-modulating G protein-coupled receptor signaling pathway adrenergic receptor signaling pathway angiotensin-activated signaling pathway apelin receptor signaling pathway bombesin receptor signaling pathway ... Show All 42 Terms

adenylate cyclase-modulating G protein-coupled receptor signaling pathway adrenergic receptor signaling pathway angiotensin-activated signaling pathway apelin receptor signaling pathway bombesin receptor signaling pathway calcitonin family receptor signaling pathway cannabinoid signaling pathway chemokine-mediated signaling pathway cholecystokinin signaling pathway complement component C5a signaling pathway endothelin receptor signaling pathway follicle-stimulating hormone signaling pathway G protein-coupled acetylcholine receptor signaling pathway G protein-coupled chemorepellent receptor signaling pathway G protein-coupled dopamine receptor signaling pathway G protein-coupled glutamate receptor signaling pathway G protein-coupled opioid receptor signaling pathway G protein-coupled opsin signaling pathway G protein-coupled purinergic receptor signaling pathway G protein-coupled receptor signaling pathway involved in dauer larval development G protein-coupled receptor signaling pathway involved in defense response to Gram-negative bacterium G protein-coupled receptor signaling pathway involved in heart process G protein-coupled receptor signaling pathway involved in social behavior G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger G protein-coupled serotonin receptor signaling pathway gastric inhibitory peptide signaling pathway ion channel modulating, G protein-coupled receptor signaling pathway leukotriene signaling pathway luteinizing hormone signaling pathway neuropeptide signaling pathway octopamine or tyramine signaling pathway phospholipase C-activating G protein-coupled receptor signaling pathway phospholipase C-inhibiting G protein-coupled receptor signaling pathway phospholipase D-activating G protein-coupled receptor signaling pathway potassium channel activating, G protein-coupled receptor signaling pathway Rho-activating G protein-coupled receptor signaling pathway somatostatin receptor signaling pathway sphingosine-1-phosphate receptor signaling pathway tachykinin receptor signaling pathway thrombin-activated receptor signaling pathway thromboxane A2 signaling pathway thyroid-stimulating hormone signaling pathway Show first 5 Terms
has_part: G protein-coupled receptor activity

G protein-coupled receptor activity Show first 5 Terms
negatively regulated by: negative regulation of G protein-coupled receptor signaling pathway

negative regulation of G protein-coupled receptor signaling pathway Show first 5 Terms
positively regulated by: positive regulation of G protein-coupled receptor signaling pathway

positive regulation of G protein-coupled receptor signaling pathway Show first 5 Terms
regulated by: regulation of G protein-coupled receptor signaling pathway

regulation of G protein-coupled receptor signaling pathway Show first 5 Terms

Phenotype

Phenotype caused by Genes