complement activation

Term ID

GO:0006956

Synonyms

complement activity
complement cascade
complement response

Definition

Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway. 0781735149

References

Reactome:R-HSA-166658

Ontology

GO: Biological Process QuickGO AmiGO

Relationships

is a type of: activation of immune response humoral immune response immune effector process

activation of immune response humoral immune response immune effector process Show first 5 Terms
has subtype: activation of membrane attack complex complement activation, alternative pathway complement activation, classical pathway complement activation, lectin pathway

activation of membrane attack complex complement activation, alternative pathway complement activation, classical pathway complement activation, lectin pathway Show first 5 Terms
has_part: protein activation cascade

protein activation cascade Show first 5 Terms
inverse has_part: complement-dependent cytotoxicity

complement-dependent cytotoxicity Show first 5 Terms
negatively regulated by: negative regulation of complement activation

negative regulation of complement activation Show first 5 Terms
positively regulated by: positive regulation of complement activation

positive regulation of complement activation Show first 5 Terms
regulated by: regulation of complement activation

regulation of complement activation Show first 5 Terms

Phenotype

Phenotype caused by Genes