phosphatidylinositol 3-kinase complex, class IA

Term ID

GO:0005943

Synonyms

• 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex
• 1-phosphatidylinositol-4-phosphate kinase, class IA complex
• class IA PI3K complex
• phosphoinositide 3-kinase complex, class IA

Definition

A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways. (2)

References

Ontology

GO: Cellular Component    QuickGO    AmiGO