guanyl-nucleotide exchange factor activity

Term ID

GO:0005085

Synonyms

• ARF guanyl-nucleotide exchange factor activity
• cAMP-dependent guanyl-nucleotide exchange factor activity
• GDP-dissociation stimulator activity
• GDS
• GEF
• GNRP
• guanyl-nucleotide release factor activity
• guanyl-nucleotide releasing factor
• Rab guanyl-nucleotide exchange factor activity
• Rac guanyl-nucleotide exchange factor activity
• Ral guanyl-nucleotide exchange factor activity
• Ran guanyl-nucleotide exchange factor activity
• Rap guanyl-nucleotide exchange factor activity
• Ras guanyl-nucleotide exchange factor activity
• Rho guanine nucleotide exchange factor
• Rho guanyl-nucleotide exchange factor activity
• RhoGEF
• Sar guanyl-nucleotide exchange factor activity

Definition

Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. (2)

References

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Ontology

GO: Molecular Function    QuickGO    AmiGO