NMDA glutamate receptor activity

Term ID

GO:0004972

Synonyms

N-methyl-D-aspartate selective glutamate receptor activity
NMDA receptor

Definition

A cation channel that opens in response to binding by extracellular glutmate, but only if glycine or D-serine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages. (2)

References

Wikipedia:NMDA_receptor

Ontology

GO: Molecular Function QuickGO AmiGO

Relationships

is a type of: glutamate-gated receptor activity inorganic cation transmembrane transporter activity voltage-gated monoatomic ion channel activity

glutamate-gated receptor activity inorganic cation transmembrane transporter activity voltage-gated monoatomic ion channel activity Show first 5 Terms
inverse has_part: NMDA selective glutamate receptor signaling pathway

NMDA selective glutamate receptor signaling pathway Show first 5 Terms
negatively regulated by: negative regulation of NMDA glutamate receptor activity

negative regulation of NMDA glutamate receptor activity Show first 5 Terms
positively regulated by: positive regulation of NMDA glutamate receptor activity

positive regulation of NMDA glutamate receptor activity Show first 5 Terms
regulated by: regulation of NMDA receptor activity

regulation of NMDA receptor activity Show first 5 Terms

Phenotype

Phenotype caused by Genes